Andrew L. Wentland1,2, Nathan Artz1, Arjang Djamali3, Thomas M. Grist2, Garima Agrawal2, Sean B. Fain1,2, Elizabeth A. Sadowski2
1Medical Physics, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA; 2Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA; 3Nephrology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA
Non-contrast methods of assessing renal function are important to investigate, given the recent link between nephrogenic systemic fibrosis and gadolinium based contrast agents. Perfusion using non-contrast ASL methods and oxygen bioavailability measurements using BOLD MRI were obtained during states of pharmacologically and physiologically induced increases and decreases in renal perfusion in swine. Heart rate, blood pressure, and urine output were simultaneously monitored during the experiment. Preliminary results with ASL perfusion and BOLD oxygenation measurements show expected changes in each state of increased or decreased perfusion, with corresponding alterations in blood pressure and urine output.