Abstract #1805

Comparison of Self Gated Cardiac MRI with Echocardiography for Determination of Left Ventricular Function in Rodent Models of Hypertrophy

kirsten Gilday¹, chris McCabe², William Matthew Holmes², Mhairi Macrae², anna Dominiczak¹

¹BHF Glasgow Cardiovacular Research Centre, University of Glasgow, UK; ²Clinical Neuroscience, University of Glasgow, Glasgow, Scotland, UK

The stroke-prone spontaneously hypertensive rat (SHRSP) is an excellent experimental model of essential hypertension. In addition, this strain demonstrates left ventricular hypertrophy. In humans, echocardiography and MRI are used as quick, non-invasive and accurate procedures for measuring cardiac parameters.The aim was to demonstrate the validity of echocardiography and self gated cardiac MRI as high fidelity, high throughput techniques for characterising cardiac differences in mass and function in 16 week old SHRSP, normotensive Wistar Kyoto (WKY) rats and the congenic strain SP.WKYGla14a.