Abstract #1538

Comparing Kidney Perfusion Using Arterial Spin Labeling and Microsphere Methods in an Interventional Swine Model

Nathan Artz¹, Andrew Wentland¹, Elizabeth Sadowski², Zhifei Wen¹, Thomas Grist^1,2, Arjang Djamali³, Sean Fain^1,2

¹Medical Physics, University of Wisconsin, Madison, WI, USA; ²Radiology, University of Wisconsin, Madison, WI, USA; ³Nephrology, University of Wisconsin, Madison, WI, USA

Two methods of measuring cortical kidney perfusion, fluorescent microspheres and ASL-FAIR, are compared for 5 swine at four time points: under baseline conditions, during an acetylcholine and fluid bolus challenge, and at baseline and after 2 hours of isoflurane anesthesia with ice placed on one of the kidneys. ASL correlates well with microspheres at every time point during the experiment, with a rho = 0.7.