Linda Knutsson1, Anna Rydhg1, Danielle van Westen2, Stig Holts2, Freddy Sthlberg2,3, Ronnie Wirestam1
1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2Department of Diagnostic Radiology, Lund University, Lund, Sweden; 3Department of Medical Radiation Physics, Lund University , Lund, Sweden
Reproducible absolute quantification of cerebral blood volume (CBV) and cerebral blood flow (CBF) by dynamic susceptibility contrast MRI (DSC-MRI) is difficult to achieve, for example, due to partial-volume effects (PVEs). The purpose of this study was to correct for arterial PVEs by rescaling the AIF using a VOF obtained by injecting a fraction of the contrast-agent dose as a pre-bolus. During the pre-bolus passage, a segmented EPI sequence in single-slice mode was used to register the VOF in the superior sagittal sinus. Our results showed that our proposed correction method removed a substantial amount of arterial PVEs.