John Robert Cain1, Gerard Thompson1, Samantha Jane Mills1, Alan Jackson1
1Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK
A reproducibility study of two quantitative measures of apparent diffusion coefficient (ADC) image tumour boundaries. ADC Transition Coefficient into Oedema (ATCO) is a measure of change of ADC signal across the interface between oedema and white matter, ADC Transition Coefficient into Tumour (ATCT) is a measure of change of ADC signal across the oedema/solid tumour interface. Twenty-three patients with glioma were imaged on a 3T system, ADC images were analysed by two radiologists using a clearly defined method. These measures are simple, quick to perform and have excellent reproducibility, interclass correlation coefficient 0.895 and 0.834 for ATCO and ATCT respectively.