Abstract #1368

Treatment Response of Non-Monoexponential Diffusion in a Glioma Rodent Model

Benjamin Hoff¹, Denis Le Bihan², Alnawaz Rehemtulla³, Thomas Chenevert¹, Brian Ross¹, Craig Galbn¹

¹Radiology, University of Michigan, Ann Arbor, MI, USA; ²NeuroSpin, CEA, Saclay, France; ³Radiation Oncology, University of Michigan, Ann Arbor, MI

Diffusion MRI at low b-values (~1000 s/mm2) has shown promise as an early surrogate biomarker of treatment response in glioma patients. Recent studies have shown that at higher b-values (>3000 s/mm2) signal attenuation by diffusion deviates from monoexponential behavior in biological tissue. The aim of this study was to test the response of the apparent diffusion coefficient (ADC) calculated from various non-monoexponential models against a conventional two-point low b-value method following chemotherapy in a rodent brain tumor model.