Shigeyoshi Saito1, Kazuhiko Sawada2, Xue-Zhi Sun3, Tetsuya Suhara4, Iwao Kanno4, Ichio Aoki4
1Department of Molecular and Neuroimaging, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; 2Laboratory of Anatomy, Department of Physical Therapy, Faculty of Medical and Health Sciences, , Japan; 3Regulation Science Research Group, National Institute of Radiological Sciences, Chiba, Japan; 4Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
In vivo evaluation of radiation damage in the CNS is important for the assessment and treatment. Our goal is to investigate differences in the longitudinal dynamics between normal and irradiated subjects using Gd-DTPA, Mn2+ T1 agents, and perfusion imaging (EPI-FAIR). In addition, the contribution of the BBB permeability was tested between 1-week neonatal and 2-week rats. Gd-DTPA and perfusion MRI is a useful technique for BBB and microcirculation assessment in subjects exposed to ionizing radiation. Mn2+ contrast agents used in conjunction with T1 mapping can be used as a cellular density/activity indicator for a neonatal animal.