Feng-Xian Yan1, Shwu-Hua Lee2, Han-Jung Ko2, Ho-Ling Liu3,4
1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; 2Department of Psychiatry, Chang Gung Medical Hospital, Kwei-Shan, Tao-Yuan, Taiwan; 3Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan; 4MRI Center, Chang Gung Medical Hospital, Kwei-Shan , Tao-Yuan, Taiwan
Previous researches have found decreased regional cerebral volume, involving frontal, temporal, parietal cortex in the late-life depression. This study aimed to analyze the regional cortical thickness in patients with late-life depression and compare with normal aged subjects. The results showed reduced cortical thickness in orbitofrontal regions in patients with late-life depression, which agreed well with previous studies. In addition, other brain areas appeared thicker in patients than controls, such as in cingulate gyrus and parietal lobule etc. Those areas may play important roles as compensatory to the behavior changes in attention and executive functions in patients with late-life depression.