Pascal Sati1, Anne H. Cross2, Robert E. Schmidt3, Dmitriy A. Yablonskiy4
1Department of Radiology, Washington University School of Medecine, St Louis, MO, USA; 2Department of Neurology, Washington University School of Medicine, St Louis, MO, USA; 3Department of Pathology, Washington University School of Medecine, St Louis, MO, USA; 4Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
Application of GEPCI technique for in vivo evaluation of brain MS lesions demonstrated substantial improvement in image quality and saving of acquisition time as compared to current clinical MR sequences. However, ex vivo studies and comparison with pathology is required to validate this method. Herein we apply GEPCI technique for investigations on MS and control postmortem brains, and compare results with data obtained by standard MRI protocols. We show that GEPCI technique has the potential to provide new information about the abnormalities in MS tissue while being as reliable as conventional MRI techniques for detection of MS lesions.