Preliminary Study of the Brain in Patients with Amyotrophic Lateral Sclerosis by Using Susceptibility-Weighted Imaging

Lin Ma¹, Mengyu Liu¹

Hypointense signal, also known as motor dark line, are frequently seen in bilateral precentral gyri in patients with amyotrophic lateral sclerosis (ALS). The reason for the low signal remains unknown. SWI was used to explore the possible susceptibility differences between ALS patients and normal controls in this prospectively designed study. The result showed the phase shift value was significantly lower in ALS patients than in controls only in precentral gyri, indicating that substances with stronger susceptibility may exist in precentral gyri in ALS.