Abstract #1105

Enhanced Regional CBF in Patients with Mild Alzheimers Disease After Three Months of Aricept Treatment

Wenjun Li¹, Chunming Xie^1,2, Zhilin Wu¹, Jennifer Jones³, Piero Antuono³, Thomas McRae⁴, Shi-Jiang Li^1,5

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA; ²Neurology, School of Clinical Medicine, Southeaset University, Nanjing, Jiang Su, China; ³Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; ⁴Pfizer, Inc.; ⁵Psychiatry, Medical College of Wisconsin, Milwaukee, WI, USA

The aim of the current study was to investigate the effects of Aricept treatment on CBF perfusion in Alzheimer's disease (AD) by using arterial spin-labeling perfusion MRI (ASL-MRI) [3] to measure regional CBF.