Graham S. Flory1, Kathleen A. Grant1,2, Christopher D. Kroenke1,3
1Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA; 2Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA; 3Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA
It has previously been suggested that the ethanol methyl 1H in vivo magnetic resonance spectroscopic (MRS) signal amplitude is larger, per unit concentration, in individuals that are tolerant to ethanols intoxicating effects than in non-tolerant individuals. To investigate this possibility, a link between the brain ethanol binding potential (BP) and 1H methyl T2 value is proposed. Experimental support for the analytic relationship is obtained from a series of in vivo MRS measurements of rhesus monkey brain following intravenous administration of 0.5, 1.0, and 1.5 g/kg ethanol.