Fang Fang1, Hao Lei1
1Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China
In this study, in vivo 1H MRS was used to measure the NAA/tCr ratio in the hippocampus of rats treated with pentylenetetrazol (PTZ) for 28 days. The results showed that the PTZ-treated rats had significantly lower hippocampal NAA/tCr ratio than the control animals. The extents of neuronal injuries in the hippocampus of PTZ-treated rats appeared to be dependent on the history of the seizures occurred during the course of epileptogenesis.