Benjamin Lemasson1,2, Thomas Christen1,3, Nicolas Pannetier1,3, Rgine Farion1,3, Christoph Segebarth1,4, Xavier Tizon2, Peggy Provent2, Philippe Genne2, Emmanuel L. Barbier1,3, Olivier Duchamp2, Chantal Rmy1,3
1Inserm, U836, Grenoble, F-38043, France; 2Oncodesign Biotechnology, Dijon, France; 3Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, F-38043, France; 4Universit Joseph Fourier, Grenoble Institut des Neurosciences, UMR-S836, Grenoble, F-38043, France
Glioma tumors are highly angiogenic, therapies directed against tumor vasculature or preventing angiogenesis have been developed. Monitoring changes in structural and functional microvasculature should help to evaluate the efficiency of these therapies. This study shows structural (Blood Volume fraction and Vessel Size Index) and functional (Blood Brain Barrier permeability and local Blood Oxygen Saturation) modification in response to an anti-angiogenic treatment used alone or combined to a chemotherapy on an orthotopic human glioma model (U87-MG) xenografted in nude rat. lSO2 seems to be a sensitive reporter of antiangiogenic therapeutic effect and to provide independent information from BVf, VSI and BBBpem.