Abstract #0920

Evaluation of Nanoparticle Contrast Agent Uptake in Murine Microglia (Bv-2) and Human Teracarcinoma (NT2) for Cell Tracking in Neurodegenerative Disease at 21.1 T

Jens Thorvald Rosenberg^1,2, Joshua M. Kogot³, Chris Ridel³, Geoffery F. Strouse³, Samuel C. Grant^1,2

¹The National High Magnetic Field Laboratory, Tallahassee, FL, USA; ²Chemical and Biomedical Engineering, Florida State University, Tallahassee, FL, USA; ³Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA

We have assessed murine microglia cells (Bv-2) and human teratocarcinoma cells (NT2) for future use with a novel bimodal MR contrast agent. These cells can be used to identify regions of neurodegeneration. To evaluate contrast enhancement, we have compared the performance of our bimodal agents consisting of Dy-label quantum dots to SPIOs and Dy chelates (DOTA and DTPA).