Craig K . Jones1, Alex Li2, Ravi S. Menon1,2, Robert Bartha1,2
1CFMM, Robarts Research Institute, UWO, London, ON, Canada; 2Dept of Medical Biophysics, UWO, London, ON, Canada
On-resonance PARACEST contrast uses a short, low power 360 Waltz pulse to induce a signal intensity change in the measured water due to PARACEST compounds. In vivo this results in a significant decrease in the measured water signal due to the macromolecules. A post-saturation delay increases the contrast to noise ratio by a factor of 2 or more. The optimal delay depends on voxel T1 but a delay between 300 and 400 ms is sufficient for the Tm-DOTAM-glycine-lysine tested.