About the Origins of Enhanced Visualization of Amyloid Plaques on APP/PS1 Mouse Brain Using GdDOTA Passive Staining

Benjamin Marty¹, Julien Flament¹, Julien Valette¹, Fawzi Boumezbeur¹, Marc Dhenain¹, Franck Lethimonnier¹, Sbastien Mriaux¹

The present study shows the interest of passive staining and T2* weighted images to detect amyloid plaques on a APP/PS1 mouse brain. It also focus on the diffusion of contrast agent during this experiment and the consequences on the contrast of images. It shows that an important contrast in proton density appears added to the existent T2* contrast.