Olivier Maciej Girard1,2, Ahmet Erten2,3, Mark Bydder1, Milan T. Makale2, David A. Cheresh2, David Gilderdale4, Sadik Esener2,3, Robert Frederick Mattrey1,2
1Department of Radiology, University of California, San Diego, CA, USA; 2Moores Cancer Center, University of California, San Diego, CA, USA; 3Electrical Engineering , University of California, San Diego, CA, USA; 4PulseTeq, UK
Magnetic Resonance Imaging (MRI) holds significant promise to achieve quantitative analysis of tumor vasculature. However with deep tumor MRI there is no means by which to validate in vivo methods and results, especially those of a dynamic nature. We report here on the design and fabrication of a MRI and light microscope compatible window chamber, and initial time course data following Gd injection. Such a system is a significant step toward validation of permeability measurement by MRI with the light microscope.