Qin Chen1, Su Lui2, Shu-Shan Zhang1, He-Han Tang2, Jian-Gang Wang3, Xiao-Qi Huang2, Qi-Yong Gong2, Dong Zhou1, Hui-Fang shang1
1Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; 2Huaxi MR Research Center (HMRRC)Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; 3Department of Rheumatology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Previous studies revealed that PD is associated with abnormal activity in spatially distributed neural systems by PET or SPECT. The present study aims to apply resting state fMRI to examine both regional cerebral function and functional integration in patients with PD. Eleven right handed PD patients and ten healthy controls were recruited in this study. Amplitude of low-frequency (0.01C0.8 Hz) fluctuations (ALFF) of the blood oxygenation level-dependent (BOLD) signal and functional connectivity based on a seed-voxel correlation approach was used to investigate the brain function alteration and correlation with UPDRS-III scores.