Kyle Stephan McCommis1, Thomas A. Goldstein1, Dana R. Abendschein2, Bernd Misselwitz3, Robert J. Gropler1, Jie Zheng1
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; 2Cardiovascular Division, Washington University School of Medicine, St. Louis, MO, USA; 3Bayer Schering Pharma AG, Berlin, Germany
In this ongoing study, MRI methods to quantify myocardial perfusion and oxygenation were validated in a canine model at rest and during pharmacologically induced hyperemia by PET imaging. The MRI methods can quantify myocardial blood flow (MBF), blood volume (MBV), oxygen extraction (OEF), and oxygen consumption (MVO2). A black-blood turbo spin-echo sequence was used to measure the myocardial T2, and a 2-compartment model was used to measure hyperemic myocardial OEF. MBF/MBV were determined with a turboFLASH perfusion sequence. MVO2 was determined with Ficks law. The MRI results in MBF, OEF, and MVO2 agreed well with the gold standard PET measurements.