Osamu Togao1, Shigehiro Doi2, Makoto Kuro-o2, Masaya Takahashi1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Renal fibrosis is the final common pathology of most progressive renal disease such as diabetic nephropathy and glomerulonephritis. Renal fibrosis has been widely investigated in an established animal model with unilateral ureteral obstruction (UUO). In the present study, we investigated the progression of the renal fibrosis in the animal model longitudinally by T2-weighted imaging (T2WI) and diffusion weighted imaging (DWI) to test whether MRI could provide metrics for detection and evaluation of the severity of renal fibrosis.