Weiying Dai1,2, Philip M. Robson1,2, Ajit Shankaranarayanan3, David C. Alsop1,2
1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Radiology, Harvard Medical School, Boston, MA, USA; 3Applied Science Laboratory, GE Healthcare, Menlo Park, CA, USA
The arterial spin labeling signal reflects a mixture of perfusion and arterial transit time (ATT) effects. Unfortunately, ATT can span a wide range in broad clinical populations and optimization of these scans is problematic. Perfusion and ATT can be measured with images acquired at multiple delays, but such methods decrease the sensitivity of the perfusion measurement. Here, we propose a rapid, low resolution scan at multiple labeling delays to acquire a map of ATT. This ATT map can be used to optimize an ATT insensitive perfusion acquisition or to quantify perfusion from an ATT sensitive high resolution scan.