Abstract #0583

Comparison of Different Diffusion Parameters in DWI for Differentiation of Breast Lesions at 3.0 Tesla Effects of Perfusion and Diffusion Compartments on ADC

Wolfgang Bogner^1,2, Stephan Gruber^1,2, Katja Pinker^1,2, Gnther Grabner^1,2, Andreas Stadlbauer³, Ewald Moser², Thomas Helbich¹, Siegfried Trattnig^1,2

¹Department of Radiology, Medical University Vienna, Vienna, Austria; ²MR Center of Excellence, Medical University Vienna, Vienna, Austria; ³Landesklinikum St.Plten, St.Plten, Austria

Seventy-four patients suspect for breast cancer were examined on a 3T MR system with an additional DWI protocol. The impact of different diffusion schemes on diagnostically relevant parameters such as CNR and ADC precision/accuracy was investigated. The influence of perfusion and compartment effects on the ADC were studied in the breast. The diagnostic accuracy of an optimized diffusion scheme were determined. The application of such an optimized DWI protocol at 3T provided a diagnostic sensitivity of 96% and specificity of 94% in our patient group of 69 women.