Thorsten Alexander Bley1, Kevin M. Johnson2, Oliver Wieben2, Christopher J. Francois1, Scott B. Reeder1, Mark L. Schiebler1, Darren P. Lum1, Thomas M. Grist1
1Radiology, University of Wisconsin - Madison, Madison, WI, USA; 2Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA
This study evaluates noninvasive assessment of transstenotic pressure gradients (TSPG) utilizing phase contrast with vastly under sampled isotropic projection reconstruction (PC VIPR) MRA for quantification of renal artery stenosis (RAS) in a porcine model. TSPG over surgically created bilateral RAS in 11 swine were compared to invasive endovascular pressure measurements obtained with pressure sensing guidewires. Excellent correlation of TSPG assessed with PC VIPR and the gold standard were found (Pearson correlation coefficient of 0.977), indicating the feasibility of this novel method for noninvasive assessment of the hemodynamic severity of RAS.