Investigation of Tract-Specific Myelin Content Measures from a Population Averaged Myelin Water Fraction Atlas

Sean CL Deoni¹

Here we report on the development of a whole-brain, population-averaged atlas of myelin content derived from in vivo measurements of the myelin water fraction. 14 healthy individuals were imaging using the mcDESPOT multi-component relaxometry technique, non-linearly coregistered to standard space and averaged. From the resulting whole-brain atlas we demonstrate white matter tract-specific measures and consider the future application of such an atlas for identifying disease-related change.