Rasmus Matthias Birn1, Daniel Handwerker1, Peter A. Bandettini1
1Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD, USA
The amplitude of the BOLD response across the brain depends strongly on the variations in the underlying vasculature, making it difficult to determine subtle differences in neuronal activity between regions or subjects. In this study we test various calibration techniques designed to account for spatial variability in the vasculature, and compare their ability to pull out known subtle underlying variations in neuronal activity.