Using Magnanese-Enhanced MRI to Monitor the Efficacy of Angiotensin Converting Enzyme Inhibitor Treatment in a Murine Myocardial Infarction

Collier Gladin¹, Lynsa Nguyen¹, Christopher Middleton¹, Jimei Liu¹, Nathan Yanasak¹, Tom C.-C. Hu¹

There is a critical, yet unexplored, niche for using a non-invasive in vivo imaging technique to compare pharmaceutical treatment and assess the diagnostic improvement of ischemic tissue following myocardial infarction. This study demonstrates the ability of MEMRI to quantify the efficacy of an ACEi following myocardial infarction by segmenting and analyzing areas in and surrounding the ischemic site. This information potentially can be used to determine best used methods of clinical treatment following a cardiac event.