Investigating the Sources of Phase Contrast: Iron Oxide Nanoparticle Study to Exclude Deoxyhemoglobin as a Major Source for the Gray/white Matter Phase Contrast

Jongho Lee¹, Yoshiyuki Hirano, Masaki Fukunaga¹, Afonso Silva, Jeff H. Duyn¹

An intravascular contrast agent (iron oxide nanoparticle) was used to investigate the sources of phase contrast. The result indicates that deoxy-hemoglobin is not a major source for the white and gray matter contrast.