Abstract #0014

Whole-Brain Non-Invasive Hemodynamic Imaging, Enabled by a Novel CBV-Weighted Single-Shot 3D VASO-FLAIR GRASE Sequence Combined with CBF-Weighted ASL and BOLD FMRI, Identifies Regional Hemodynamic and Metabolic Discrepancies

Manus J. Donahue¹, Jakob U. Blicher², Bradley J. MacIntosh¹, Karla L. Miller¹, Leif Ostergaard², David A. Feinberg^3,4, Matthias Guenther³, Peter Jezzard¹

¹Clinical Neurology, The University of Oxford, Oxford, UK; ²Center for Functionally Integrative Neuroscience, Arhus University Hospital, Arhus, Denmark; ³Advanced MRI Technologies, Sebastopol, CA, USA; ⁴University of California at Berkeley, Berkeley, CA, USA

VASO-FLAIR magnetization preparation, previously limited to single-slice imaging, is appended to a single-shot 3D-GRASE readout to generate whole-brain CBV-weighted maps. CBV-weighted courses are compared to BOLD and CBF-weighted ASL during and following motor and visual stimulation. The 3D-GRASE VASO-FLAIR approach gives similar CBV traces to those found from single-slice techniques and corresponds well with BOLD and ASL. Following stimulation, the BOLD post-stimulus undershoot is larger and endures longer in visual cortex compared to motor cortex, whereas CBV and CBF returns to baseline at the same time.