Abstract #3494

Knowles B, Walker-Samuel S, deSouza N, Leach M, Collins D

T1 calculation using a look up table is a fast and accurate method often used in DCE-MRI. Many functions can be used to create a look up table, and five different functions were compared. Look up tables were used to create concentration time curves from clinical data. A pharmacokinetic model was fit to the curves, and values of Ktrans, ve and kep were compared. We recommend the use of an inverse (y = a + b/x) function for use in gradient echo DCE-MRI, as there is a theoretical basis for using this function, and error propagation is additive.