Abstract #3462

Song I, Hong Y, Lee K, Chang K, Na D

We developed a so-called two-ROI approach in which 3D fiber bundle tracking was performed using two reference ROIs to delineate the corticospinal tract in patients with amyotrophic lateral sclerosis (ALS). Reliability of this approach was analyzed, and the possible changes of diffusion properties were assessed. FA is highly variable along the corticospinal tract in DTI maps, which indicates that possible mismatching in anatomical levels and boundary of ROI can affect the result. Two-ROI approach may reduce such an operator-induced bias in defining a ROI, and can be used as a reliable tool for demonstrating the corticospinal tract degeneration in ALS.