Abstract #3459

Arfanakis K, Peng H, Fitzgerald D, Coccaro E, Phan K

Intermittent explosive disorder (IED), which is characterized by episodic, impulsive aggression, is an important social and clinical problem. The purpose of this investigation was to study the diffusion characteristics of the whole brain in patients with IED. Turboprop-DTI was used in this study, in order to produce DTI data that are relatively free of susceptibility-related artifacts in regions such as the frontal and temporal lobes. A significant reduction of FA was detected in the fornix, forceps minor, and posterior cingulate cortex of patients with IED compared to healthy controls.