Abstract #3225

Matsuda, RT T, Kimura, MD, PhD H

MEGA-PRESS method is used for evaluation of GABA by clinical setting. We propose the optimization of echo time to increase NMR signal from GABA based on MEGA-PRESS methods. We show that the signal intensity of the GABA obtained MEGA-PRESS with TE61ms was higher than TE68ms spectrum which TE calculated from J-coupling both in vivo and vitro condition. Although the signal gain may be small using TE=61ms instead of TE 68ms in GABA editing acquisition, this is very important especially for the clinical application, since the acquisition time is limited in clinical setting.