Abstract #3136
Mouse spinal cord ventrolateral white matter diffusion anisotropy indices do not change in situ up to 10 hours postmortem
Kim J, Song S
Washington University
The DTI derived anisotropy indices of ventrolateral white matter from normal mouse spinal cord in vivo, in situ at various times postmortem, and postmortem after immersion fixation were determined. The relative anisotropy (RA), and trace normalized axial (D||) and radial (D) diffusivities remained unchanged comparing in vivo, in situ postmortem, and postmortem formalin fixed states. This finding supports the application of postmortem DTI measurements with immersion fixed autopsy specimens.
