Abstract #2915

McGrath D, Lacey T, Bradley D, Taylor C, Parker G

DCE-MRI is used in anti-vascular therapies to quantify parameters associated with vascular function. In compartmental modelling it is necessary to identify an appropriate arterial input function (AIF). It was sought to assess the effects of using various AIF models. Using experimentally acquired high temporal resolution data from rats, four different AIF models were fitted to the data and compared with the use of the raw AIF data by calculating the parameters from the extended Kety model. It was observed that varying AIF models impact results highly, and was recommended that a bi-exponential model provides the closest modelling of experimental AIFs.