Abstract #2720

Huang T, Chou M, Hsu C, Liu Y, Juan C, Chen C, Chung H

Diffusion tensor imaging technique has been widely applied in the investigation of cerebral anisotropy in healthy subjects, aging brain and cerebral pathology using apparent diffusion coefficient (ADC) and fractional anisotropy (FA). The purpose of this study is to elucidate the geographic difference of the diffusion anisotropy of the cerebral gray and white matter using a three-phase (3P) plotting method and a bivariate distance measurement (d3p) in the aging brain. Our results show significant age-related decline in FA, Cl and Cp parameters and significant age-related increase in ADC and Cs in both white matter and gray matter of the aging brain.