Abstract #2220

Devire J, Matos C, Bali M, Metens T, Arvanitakis M

The aim of this study was to evaluate the stimulating effect of two doses of secretin on pancreatic exocrine secretions using MRCP. This study has been realized in ten healthy volunteers. MRCP was repeated two times in each volunteer for each dose (1 and 0.3 CU/Kg). Pancreatic flow output and total excreted volume were derived from a linear regression between MR calculated volumes and time. In all examinations, pancreatic exocrine fluid volume increased linearly with time. Mean pancreatic flow output and total excreted volume were significant lower at the dose of 0.3 CU. Pancreatic exocrine function reacts proportionally to the degree of stimulation.