Abstract #1759

Wang J, Wolf R, Melhem E, Poptani H, Wang S, Chawla S, Woo J, Grady M, Judy K, O' Rourke D

The study was performed to ascertain whether combined use of CASL and 1H-MRSI can differentiate low from high-grade oligodendrogliomas. 1H-MRSI and CASL imaging was performed on eleven patients. Average CBF from solid parts of the tumor were normalized to contralateral white matter and assigned as CBFT/W. Absolute concentrations of metabolites from these regions were normalized to contralateral white matter. Although CBF T/W could not differentiate between high-grade and low-grade oligodendrogliomas, 1H-MRSI exhibited high ChoT/W and Lip/Lac T/W in high grade-III tumors than grade-II oligodendrogliomas suggesting a complementary role of the two MR techniques.