Abstract #1621

Ramadan S, Mountford C

Correlation of diffusion coefficient with other molecular properties has been used to gain insight into molecular structures and dynamics. A diffusion-exchange weighted (DEW) sequence has been developed to measure ADC with exchange in a 3T whole body MR scanner. The exchange of protons from one compartment to another, with different ADCs, provides insight into physical properties of tissue. The ADC in the brain was found to be dependent on exchange time, with ADC decreasing with increased exchange time. The DEW imaging technique can also increase contrast to the image based on the exchange property, a function of various cell properties.