Abstract #0575

Lowry M, Manton D, Tan P, Turnbull L

We report here an investigation into both imaging and spectroscopic methods of measuring the water T2 of malignant breast lesions, and their utility in predicting response to neoadjuvant chemotherapy, both alone and in combination with lesion volumes. We found that imaging and spectroscopy produced similar T2 values, and the ratio of the product of the lesion T2 and volume after the 2nd cycle to those pre-treatment is a good predictor of ultimate lesion response, with PPV and NPV of 95.5% and 84.6% respectively.