Diffusion MRI has an important role in research of the aging brain. Diffusion MRI can help elucidate the role of brain characteristics in the mechanisms supporting cognitive and motor health or leading to cognitive and motor decline in old age. Combining diffusion MRI with other imaging, clinical, neuropsychological, and most importantly neuropathologic information may provide invaluable insights towards the development of useful biomarkers of age-related diseases. To successfully accomplish the above, however, it is important to first realize the intricacies of conducting meaningful diffusion imaging investigations of the older adult brain.
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