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Abstract #8402

13C Metabolic Fluxes, not Hyperpolarized

Douglas L. Rothman1

1Yale University

An introduction to the use of 13C and 1H-13C MRS to measure metabolic fluxes in pre clinical models and clinical research studies will be presented. The presentation will have the following sections: 1. introduction to 13C MRS 2. use of 13C MRS to measure metabolite labeling 3. calculations of metabolic fluxes from metabolite labeling curves 4. applications to study metabolism in health and disease 5. application to study therapy. The main goals are to provide the audience with basic knowledge of how to perform and interpret 13C MRS measurements of metabolic fluxes and their potential for use in clinical research.

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