In acute stroke imaging, the “penumbra” usually refers to brain tissue that is considered to be at risk for infarction. Identification of the penumbra is consistently a focus of active imaging research, particularly in the development of strategies for selecting patients for intravenous thrombolysis and mechanical thrombectomy. Penumbral imaging approaches usually employ perfusion imaging, which provides a variety of complementary measurements of cerebral hemodynamics at the microvascular level. This talk will explore the relationship of penumbral imaging to fundamental principles of cerebrovascular physiology, addressing both currently implemented penumbral imaging techniques, and potential novel applications of perfusion imaging in stroke care.
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