TBI is devastating yet currently without a cure. Investigators are seeking therapeutic strategies through the preclinical animal model to elucidate changes occurring after brain injury and identify potential neuroprotective therapies for brain-injured patients. The choice of animal model depends on the research goal and underlying objectives. This lecture will introduce the animal models of TBI commonly used for MRI study and explain their biomechanical, pathological and neurological differences in characteristics. Recent advances of MRI in probing the pathophysiology responses in experimental TBI will also be reviewed.