Enduring neuroimaging controversies exist in the study
of traumatic brain injury (TBI) especially related to mild TBI (mTBI). The presentation begins with a brief historical
overview of various definitional statements as to what constitutes a TBI,
especially involving “concussion.” Although
various lesion quantification methods have become standard, when to scan post-injury
and what to quantify remain part of the debate. Individual differences and the heterogeneity
of the injury complicate and may mask effects at the individual level. With advanced
neuroimaging techniques, controversies remain as to acquisition,
post-processing and study design questions and what outcome metrics should be
examined.
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