Most diffusion MRI is today performed with the so-called pulsed gradient spin echo (PGSE) method, which encodes for diffusion using two gradient pulses. This method is sensitive to cellularity of tumours, orientation of white matter tracts, and microstructure features such as axon density and cell sizes. However, the PGSE method is fundamentally limited in several ways. This talk will pinpoint these limitations and show how novel gradient waveforms can overcome them.
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