Measuring the brain perfusion responsive to the external vasodilators, termed cerebrovascular reactivity (CVR), is a useful tool towards better understanding of brain pathophysiological conditions, such as arterial stenosis, brain tumor, dementia, and traumatic brain injury. Moreover, CVR evaluation could serve as a novel approach to normalize the BOLD fMRI signal and quantify neural activity evoked by stimulation in calibrated fMRI as well, paving the way for neuroscience research.
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