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Abstract #8080

Microstructural Effect on Susceptibility

Jeff Duyn

High field studies have brought to light not only that the composition of tissues affects MRI susceptibility contrast, but also that a tissue’s sub-voxel structure at scales all the way down to the molecular level plays an important role as well. In this overview, various ways will be discussed by which sub-voxel structure can affect magnetic susceptibility contrast, and the extraction of quantitative magnetic susceptibility values. In addition, opportunities study the microstructural aspects of brain tissue with susceptibility weighted MRI will be reviewed, with an emphasis for inferring the orientation of fiber bundles in white matter and the relative size of the myelin water compartment.

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