Diffuse optical imaging (DOI) is a portable imaging modality that provides the ability to perform early and continuous monitoring of brain function. Its portability overcomes many of the technical and logistical challenges of performing MRI investigations in hospitalized patients. While standard DOI systems suffer from low spatial resolution and lack of brain specificity, new developments in hardware and software have overcome many of these technical limitations. In this talk, I will introduce novel DOI techniques developed for bedside mapping of resting-state functional connectivity in neonates and adults and present multi-modal comparisons with functional MRI maps obtained in the same subjects.
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