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Abstract #8002

Application of Diffusion MRI in Animal Models

Manisha Aggarwal1

1Department of Radiology, Johns Hopkins University School of Medicine

This lecture will provide a brief overview of technical considerations involved in diffusion MRI of small animals on preclinical scanners. Applications of diffusion MRI to examine neuroanatomy and brain development in small animals will be covered. We will examine the relations between metrics derived using different diffusion models and acquisition schemes and white matter pathological changes in animal models of injury and disease. In addition, emerging applications of diffusion MRI methods for characterization of brain tissue microstructure in animal models will be explored.

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